abstract：Background:Esophageal cancer (EC) is one of the aggressive gastrointestinal malignancies. It has been reported that microRNAs (miRNAs) play key roles during the tumorigenesis of EC. To identify novel potential targets for EC, differential expressed miRNAs (DEG) between EC and adjacent normal tissues were analyzed with ...

journal_title：OncoTargets and therapy

authors： Shi W,Song J,Gao Z,Liu X,Wang W

更新日期：2020-09-24 00:00:00

abstract：:CD47 belongs to immunoglobulin superfamily and is widely expressed on the surface of cell membrane, while another transmembrane protein SIRPα is restricted to the surface of macrophages, dendritic cells, and nerve cells. As a cell surface receptor and ligand, respectively, CD47 and SIRPα interact to regulate cell migr...

journal_title：OncoTargets and therapy

authors： Lu Q,Chen X,Wang S,Lu Y,Yang C,Jiang G

更新日期：2020-09-22 00:00:00

abstract：Background:Galangin (GLN), a pure natural flavonoid compound found in plants, has been shown to exert anti-cancer effects against multiple cancer types, including glioma. However, its underlying molecular mechanism remains unclear. Epithelial-to-mesenchymal transition (EMT) performs an important function in the genesis...

journal_title：OncoTargets and therapy

authors： Xiong Y,Lai X,Xiang W,Zhou J,Han J,Li H,Deng H,Liu L,Peng J,Chen L

更新日期：2020-09-17 00:00:00

abstract：Purpose:Radioresistance is a vital obstacle for the prognosis of human nasopharyngeal carcinoma (NPC), but the underlying mechanism is still unknown. Here, we explored the role of the NRF2/KEAP1 pathway in radioresistance of NPC cell lines. Materials and Methods:We selected NPC cell lines CNE-1 and CNE-2, treated them...

journal_title：OncoTargets and therapy

authors： Zhou J,Ding J,Ma X,Zhang M,Huo Z,Yao Y,Li D,Wang Z

更新日期：2020-09-11 00:00:00

abstract：Objective:Sanguinarine (SNG) is a benzophenanthridine alkaloid obtained from the roots of Sanguinaria canadensis and has an anticancer effect. The aim of this study was to explore the mechanism of SNG in inhibiting macrophages via regulating the exosomes derived from lung carcinoma cells to reduce metastasis and prolif...

journal_title：OncoTargets and therapy

authors： Yu Y,Luo Y,Fang Z,Teng W,Yu Y,Tian J,Guo P,Xu R,Wu J,Li Y

更新日期：2020-09-10 00:00:00

abstract：Purpose:This study is aimed to investigate the combined treating efficacy of sodium butyrate and docetaxel on proliferation and apoptosis of the lung adenocarcinoma A549 cell line based on Gli1 regulation in vitro and in vivo. Materials and Methods:RNA interference method was used to overexpress Gli1 in A549 cells. Ce...

journal_title：OncoTargets and therapy

authors： Chen M,Jiang W,Xiao C,Yang W,Qin Q,Mao A,Tan Q,Lian B,Wei C

更新日期：2020-09-04 00:00:00

abstract：Background:Huaier extract has been a part of traditional Chinese medicine (TCM) for roughly 1600 years and may serve as a potential anti-cancer drug as it is associated with good efficacy and low toxicity. Individuals with inflammatory bowel disease (IBD) are at a higher chance of being diagnosed with colorectal cancer...

journal_title：OncoTargets and therapy

authors： Zou YF,Rong YM,Chen ZX,Shen ZH,Chen X,Tan YX,Weng JR,Huang XM,Lin XT

更新日期：2020-08-26 00:00:00

abstract：Background:Bone marrow stromal antigen 2 (BST2) is considered as a transmembrane glycoprotein and plays essential roles in innate immunity. It has been recently reported that up-regulation of BST2 was associated with the development of breast carcinoma. However, the clinical significance of BST2 in glioma has not been ...

journal_title：OncoTargets and therapy

authors： Shi H,Luo K,Huang W

更新日期：2020-08-26 00:00:00

abstract：Purpose:Cervical squamous cell carcinoma (CSCC) seriously affects women's health worldwide, and it is of great significance to illuminate the specific role of circRNAs in CSCC. Materials and Methods:Three mRNA datasets, two miRNA datasets and one circRNA dataset of CSCC, downloaded from GEO, were utilized in this stud...

journal_title：OncoTargets and therapy

authors： Wu Q,Liu P,Lao G,Liu Y,Zhang W,Ma C

更新日期：2020-08-25 00:00:00

abstract：Background:Although several long non-coding RNAs (lncRNAs) have been found to be involved in gastric cancer tumorigenesis, the more comprehensive contributions of lncRNAs to gastric cancer require further investigation. Here, we identify a cytoplasmic lncRNA, LINC01485, which promotes tumor growth and migration in gast...

journal_title：OncoTargets and therapy

authors： Zhou J,Wu L,Li W,Xu X,Ju F,Yu S,Guo J,Li G,Shi J,Zhou S

更新日期：2020-08-21 00:00:00

abstract：Introduction:A disintegrin and metallopeptidase with thrombospondin motifs (ADAMTSs), whose expression is dysregulated in various cancers, is implicated in cancer development. Herein, we aimed to investigate the functional role of ADAMTS8 in breast cancer (BC) and explore the underlying mechanisms. Methods:The protein...

journal_title：OncoTargets and therapy

authors： Zhang K,Tian R,Wang G,Zhang J,Ma H,Hu X,Xi J,Wang G

更新日期：2020-08-21 00:00:00

abstract：:ALK rearrangements account for ~5% of non-small-cell lung cancer (NSCLC). Numerous rearrangement partners have been discovered. Here, we describe a 53-year-old nonsmoker with NSCLC, in whom we identified four novel rearrangements. The patient was diagnosed as adenocarcinoma in the right middle lobe of lung, with metas...

journal_title：OncoTargets and therapy

authors： Cai C,Long Y,Li Y,Huang M

更新日期：2020-08-20 00:00:00

abstract：Background:New evidence suggests that histidine triad nucleotide-binding protein 1 (Hint1) exerts a tumor suppressor effect in various human tumors, such as colorectal cancer and gastric cancer. However, it has not been reported whether Hint1 is involved in the occurrence and development of osteosarcoma (OS). Material...

journal_title：OncoTargets and therapy

authors： Duan DD,Xie H,Shi HF,Huang WW,Ding F,Hong JK,Fan JS,Hu SY,Wang QW,Zhou MQ

更新日期：2020-08-19 00:00:00

abstract：Purpose:LINC00680 was reported to be involved in various cancers through multiple mechanisms. Therefore, we intended to investigate its role in the progression of non-small cell lung cancer (NSCLC). Materials and Methods:Firstly, quantitative real-time polymerase chain reaction (qRT-PCR) was used to test LINC00680 in ...

journal_title：OncoTargets and therapy

authors： Wang H,Feng L,Zheng Y,Li W,Liu L,Xie S,Zhou Y,Chen C,Cheng D

更新日期：2020-08-18 00:00:00

abstract：Introduction:Esophageal squamous cell carcinoma (ESCC) is a malignant tumor disease with high mortality and morbidity rates, especially for a terminal cancer. At present, the prognosis and treatment of ESCC cannot effectively control or inhibit the spread and proliferation of tumor cells. microRNAs, a class of small sp...

journal_title：OncoTargets and therapy

authors： Tan Y,Lu X,Cheng Z,Pan G,Liu S,Apiziaji P,Wang H,Zhang J,Abulimiti Y

更新日期：2020-08-13 00:00:00

abstract：:Immune cells are essential for defending the body's balance and have increasingly been implicated in controlling tumor growth. In cervical cancer (CC), the immune landscape is extensively connected with human papillomavirus (HPV) status. Recent insights from studies have revealed that as a result of infection with HPV...

journal_title：OncoTargets and therapy

authors： Guo L,Hua K

更新日期：2020-08-12 00:00:00

abstract：Background:Pulmonary carcinosarcomas (PCSs) are a heterogeneous group of non-small-cell lung carcinomas (NSCLCs) with aggressiveness and a poor prognosis. Although genetic mutations of some common lung cancer subtypes have been extensively studied, the molecular characteristics of PCSs and the existence of abnormal tar...

journal_title：OncoTargets and therapy

authors： Li F,Hu S,Kong K,Cao P,Han P,Deng Y,Zhao B

更新日期：2020-08-10 00:00:00

abstract：Purpose:Stomach cancer is one of the highest incidence and mortality malignancies worldwide. Our study aimed to illustrate the somatic mutation landscape and identify molecular markers of stomach cancer. Materials and Methods:By integrated analysis of sequencing data and clinical data of stomach adenocarcinoma (STAD) ...

journal_title：OncoTargets and therapy

authors： Zhang X,Zheng P,Li Z,Gao S,Liu G

更新日期：2020-08-04 00:00:00

abstract：Purpose:Tumor-associated macrophages (TAMs) originate from monocytes and differentiate into mature macrophages. The interaction between cancer cells and TAMs promotes tumor growth and suppresses immunosurveillance. However, this phenomenon has seldom been observed in ampullary cancer. Patients and Methods:TAMs in ampu...

journal_title：OncoTargets and therapy

authors： Cheng LC,Chao YJ,Wang CY,Phan NN,Chen YL,Wang TW,Hsu HP,Lin YJ,Shan YS,Lai MD

更新日期：2020-08-03 00:00:00

abstract：Purpose:The microRNA (miRNA) profile changes in the tumor-associated macrophages. However, the role of miR-106b-5p in the glioblastoma-associated macrophages is poorly understood. Materials and Methods:In our study, miR-106b-5p and M2 macrophage markers were detected by qRT-PCR and Western blotting in THP1 cells, with...

journal_title：OncoTargets and therapy

authors： Shi Y,Zhang B,Zhu J,Huang W,Han B,Wang Q,Qi C,Wang M,Liu F

更新日期：2020-07-30 00:00:00

abstract：:[This retracts the article DOI: 10.2147/OTT.S215674.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2020-07-28 00:00:00

abstract：Objective:Growing epidemiological evidence supports that coagulation cascades and cancer-associated inflammation are associated with recurrence and survival of epithelial ovarian cancer (EOC). This study aimed to assess the clinical significance of the combination of plasm fibrinogen and neutrophil lymphocyte ratio (F-...

journal_title：OncoTargets and therapy

authors： Yang J,Ma J,Cheng S,Wang Y

更新日期：2020-07-27 00:00:00

abstract：Background and Objective:Metabolomics has recently been applied in the field of oncology. In this study, we aimed to use metabolomics to explore biomarkers in peritoneal metastasis of gastric cancer. Methods:Peritoneal lavage fluid (PLF) of 65 gastric cancer patients and related clinical data were collected from the F...

journal_title：OncoTargets and therapy

authors： Pan G,Ma Y,Suo J,Li W,Zhang Y,Qin S,Jiao Y,Zhang S,Li S,Kong Y,Du Y,Gao S,Wang D

更新日期：2020-07-27 00:00:00

abstract：Background:LncRNA EMX2OS (EMX2 opposite strand/antisense RNA) is notably downregulated in prostate cancer (PCa) tissues and may be regarded as a potential molecular biomarker for diagnosis and prognosis. However, its exact role in regulating the development of PCa is obscure. Methods:The EMX2OS expression was assessed...

journal_title：OncoTargets and therapy

authors： Wang Z,Zhang C,Chang J,Tian X,Zhu C,Xu W

更新日期：2020-07-21 00:00:00

abstract：Background:To investigate the effect of topical application of CpG oligodeoxynucleotide (CpG-ODN) combined with anti-4-1BB antibodies on mouse HCC multiple tumor-bearing models and the degree of improvement of anti-tumor immune response in mice. Materials and Methods:We inoculated each BALB/c male mouse subcutaneously...

journal_title：OncoTargets and therapy

authors： Ma S,Yang X,Zhou H,Zhang C,Kang J,Sun D

更新日期：2020-07-20 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) have transformed the therapeutic strategy and prognosis of advanced non-small cell lung cancer (NSCLC) patients. Nowadays, ICIs as monotherapy or in combination with chemotherapy are the standard of care treatment in advanced NSCLC, and in stage III, durvalumab (a programmed death l...

journal_title：OncoTargets and therapy

authors： Gullapalli S,Remon J,Hendriks LEL,Lopes G

更新日期：2020-07-14 00:00:00

abstract：Objective:To clarify the role and mechanism of GABPB1-AS1 in renal cell carcinoma. Methods:We collected 48 pairs of tumor and adjacent normal tissues from patients with clear cell renal cell carcinoma (ccRCC). Both 786-o and caki-1 ccRCC cell lines were transfected with GA-binding protein transcription factor subunit ...

journal_title：OncoTargets and therapy

authors： Gao S,Zhang F,Sun H,Yang X

更新日期：2020-07-12 00:00:00

abstract：:Low-grade fetal lung adenocarcinoma (L-FLAC) is an exceptionally rare pulmonary tumor, presenting with unclear histological and molecular features. In particular, the potential driver genes of L-FLAC remain elusive. To date, only five reports have documented genetic aberrations in L-FLAC. In the current study, we desc...

journal_title：OncoTargets and therapy

authors： Liu S,Wang J,Luo X,Li X,Miao Y,Wang L,Li Q,Qiu X,Wang EH

更新日期：2020-07-07 00:00:00

abstract：Introduction:Ribosome binding protein 1 (RRBP1) is reported to be correlated with tumor formation and progression. However, the role of RRBP1 in bladder cancer is unclear. In this study, we aimed to investigate the expression of RRBP1 and its influence on cell proliferation in bladder cancer. Methods:Quantification re...

journal_title：OncoTargets and therapy

authors： Lv SW,Shi ZG,Wang XH,Zheng PY,Li HB,Han QJ,Li ZJ

更新日期：2020-07-07 00:00:00

abstract：Purpose:Pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) is associated with favourable outcomes of patients with triple-negative breast cancer (TNBC). However, a proportion of TNBC patients with the residual disease do not relapse and achieve long-term survival. The aim of this study was to ident...

journal_title：OncoTargets and therapy

authors： Wei LY,Zhang XJ,Wang L,Hu LN,Zhang XD,Li L,Gao JN

更新日期：2020-07-03 00:00:00

abstract：Introduction:Gastric cancer (GC) is one of the most malignancies leading to human mortality due to its development, progress, metastasis and poor prognosis, despite the development of remarkable chemotherapy and surgery. The 5-fluorouracil (5-Fu) is an effective anti-gastric cancer agent. However, a fraction of GC patie...

journal_title：OncoTargets and therapy

authors： Gao S,Song D,Liu Y,Yan H,Chen X

更新日期：2020-07-01 00:00:00

abstract：Background:The aberrant expression of circular RNAs (circRNAs) has been identified as a novel trait of cancers. However, the role of circRNAs in colorectal cancer (CRC) remains to be elucidated. Methods:Informatic analysis was performed to identify circRNAs in CRC tissues and adjacent tissues. Gain- and loss-of-functi...

journal_title：OncoTargets and therapy

authors： Sun J,Liu J,Zhu Q,Xu F,Kang L,Shi X

更新日期：2020-06-30 00:00:00

abstract：Background:Circular RNAs (circRNAs) are a special class of noncoding RNAs that are involved in gene regulation and compete with mRNA for miRNA binding sites. The roles of circRNAs in cancer, especially breast cancer (BC), are poorly understood. Materials and Methods:The expression levels of circRNA 0001073 (circ-1073)...

journal_title：OncoTargets and therapy

authors： Yi Z,Li Y,Wu Y,Zeng B,Li H,Ren G,Wang X

更新日期：2020-06-29 00:00:00

abstract：Purpose:Numerous metabolomics studies have been conducted to detect the metabolic mechanisms and biomarkers related to gastric cancer and colorectal cancer. Because of the common metabolic features between gastric cancer and colorectal cancer, a differential diagnosis is difficult. Here, we performed a systematic revie...

journal_title：OncoTargets and therapy

authors： Tian J,Xue W,Yin H,Zhang N,Zhou J,Long Z,Wu C,Liang Z,Xie K,Li S,Li L,Wu Z,Daria V,Zhao Y,Wang F,Wang M

更新日期：2020-06-25 00:00:00

abstract：Background:Gastric cancer (GC) is an aggressive malignancy with high lethality. Systematic chemotherapy is the main therapeutic strategy for advanced GC patients. The overexpression of Axl is associated with poor prognosis and regulates tumor growth and metastasis in many types of cancer. However, the role of Axl in GC...

journal_title：OncoTargets and therapy

authors： He L,Lei Y,Hou J,Wu J,Lv G

更新日期：2020-06-22 00:00:00

abstract：Purpose:B7 homologue 6 (B7-H6) has been found at an up-regulated level in multiple cancer cells and identified to be positively correlated with inferior clinical features. In non-Hodgkin lymphoma (NHL), however, the roles of B7-H6 and the underlying mechanism of action remain unclear. Through in vivo and in vitro exper...

journal_title：OncoTargets and therapy

authors： Yang S,Yuan L,Wang Y,Zhu M,Wang J,Ke X

更新日期：2020-06-18 00:00:00

abstract：:Understanding of molecular mechanisms of tumor growth has an increasing impact on the development of diagnostics and targeted therapy of human neoplasia. In this review, we summarize the current knowledge on molecular mechanisms and their clinical implications in von Hippel-Lindau (VHL) disease. This autosomal dominan...

journal_title：OncoTargets and therapy

authors： Gläsker S,Vergauwen E,Koch CA,Kutikov A,Vortmeyer AO

更新日期：2020-06-16 00:00:00

abstract：Purpose:Breast cancer (BC) is the most common malignant cancer in women worldwide. Recently, long non-coding RNAs (LncRNAs) have been reported to have essential roles in BC tumorigenesis. Patients and Methods:Tumor and adjacent non-tumor tissue samples were collected from patients with BC (n = 168) for comparison of L...

journal_title：OncoTargets and therapy

authors： Zhang C,Wang J,Zhang J,Qu H,Tang X

更新日期：2020-06-12 00:00:00

abstract：:Erastin was initially discovered as a small molecule compound that selectively kills tumor cells expressing ST and RASV12 and was later widely investigated as an inducer of ferroptosis. Ferroptosis is a recently discovered form of cell death caused by peroxidation induced by the accumulation of intracellular lipid rea...

journal_title：OncoTargets and therapy

authors： Zhao Y,Li Y,Zhang R,Wang F,Wang T,Jiao Y

更新日期：2020-06-11 00:00:00

abstract：Background:Triple-negative breast cancer has become an intricate part and hotspot in the clinical and experimental research. Connexins, serving as functional proteins in gap junctions, play an important role in tumorigenesis, cell proliferation and metastasis. Methods:We constructed and employed the Connexin 43 (Cx43)...

journal_title：OncoTargets and therapy

authors： Fu Y,Sun X,Gu Z,Zhuang Z

更新日期：2020-06-10 00:00:00